Effect of Reduced Physical Activity on Murf-1 and Atrogin-1 Gene Expression in Soleus Muscle of Wistar Rats Following Endurance, Resistance and Combined Training

Background and Aims Understanding the involved mechanisms in muscle atrophy can help develop new treatment methods for atrophic conditions. Skeletal via biochemical transcriptional pathways increase expression of some related genes. The present study aims to assess effect reduced physical activity by spinal nerve ligation (SNL) after a period resistance, endurance combined exercises on MuRF-1 Atrogin-1 genes male rats. Methods In this experimental study, 30 Wistar rats were randomly divided into four groups: Control+SNL, exercise+SNL, resistance training+SNL. performed six weeks. After period, protocol SNL was implemented At end, soleus isolated levels measured real-time polymerase chain reaction technique. To examine gene differences between groups, analysis variance Tukey’s post hoc test used. significant level set at 0.05. Results results showed that exercise+SNL training+SNL groups significantly lower than control group (P<0.05). only compared Conclusion It seems with training are more resistant SNL-induced exercise.